The game engine struggles with very high FPS. Use third-party software (like NVIDIA Control Panel or RivaTuner) to cap the framerate to 60 FPS. Restart Chapter:

Search for "4GB Patch NTCore" (a popular, safe tool designed for this purpose). Application: Run the patcher and select your mafia2.exe file, usually located in C:\Program Files (x86)\Steam\steamapps\common\Mafia II\pc or the installation directory of your SKIDROW release.

In the game's Video Settings, disable APEX PhysX. High PhysX settings can cause massive performance drops and glitches on non-NVIDIA cards. Limit Framerate: